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La psilocibina puede ocasionar experiencias de tipo místico con significado personal y espiritual sustancial y sostenido :: Drogas México

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Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Abstract Rationale Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects. Objectives This double-blind study evaluated the...
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La psilocibina puede ocasionar experiencias de tipo místico con significado personal y espiritual sustancial y sostenido

Roland Griffiths, W.A. Richards, U. McCann, R. Jesse

Martes 11 de julio de 2006 (18/04/13)
Johns Hopkins Medicine ver en hopkinsmedicine.org

Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance



Abstract

Rationale
Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects.

Objectives This double-blind study evaluated the acute and longer-term psychological effects of a high dose of psilocybin relative to a comparison compound administered under comfortable, supportive conditions.

Materials and methods The participants were hallucinogennaïve adults reporting regular participation in religious or spiritual activities. Two or three sessions were conducted at2-month intervals. Thirty volunteers received orally administered psilocybin (30 mg/70 kg) and methylphenidate hydrochloride (40 mg/70 kg) in counterbalanced order. Toobscure the study design, six additional volunteers receivedmethylphenidate in the first two sessions and unblindedpsilocybin in a third session. The 8-h sessions were conducted individually. Volunteers were encouraged to close their eyes and direct their attention inward. Study monitorsrated volunteers’ behavior during sessions. Volunteerscompleted questionnaires assessing drug effects and mystical experience immediately after and 2 months after sessions. Community observers rated changes in the volunteer’s attitudes and behavior.Results Psilocybin produced a range of acute perceptual changes, subjective experiences, and labile moods including anxiety. Psilocybin also increased measures of mystical experience. At 2 months, the volunteers rated the psilocybin experience as having substantial personal meaning andspiritual significance and attributed to the experience sustained positive changes in attitudes and behavior consistent with changes rated by community observers.

Conclusions When administered under supportive conditions, psilocybin occasioned experiences similar to spontaneously occurring mystical experiences. The ability to occasion such experiences prospectively will allow rigorous scientific investigations of their causes and consequences.

Keywords Psilocybin .Methylphenidate .Hallucinogen.Entheogen .Mystical experience .Spiritual.Religion .Anxiety.Humans

ver en hopkinsmedicine.org


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